No matter what our discouraging situation, there are encouraging verses in the  Bible that can give us hope:

When you’ve lost something, or someone,  who has been very precious to you:
Matthew 5:4 “Blessed are those who mourn, for they shall be comforted.”
Revelation 1:18 “I am  alive forevermore.”
John 11:25 “Jesus said to her, ‘I am the resurrection and the life. He who believes in me  will live, even though he dies’”

When excruciating waves of chronic  pain and weakness are crashing over your head:
2 Corinthians 12:9 “My grace is sufficient for you, for my power is made perfect in weakness.”
Hebrews  4:16 “Let us then approach the throne of grace with confidence, so that we  may receive mercy and find grace to help us in our time of need.”

When your cupboard is bare, and your last crumb has been scraped up: 
Matthew  6:33 “Seek first God’s kingdom and His righteousness, and all these things  will be added to you.”
Psalm 23:1 “The LORD is my shepherd, I shall not be in want.”
1 Thessalonians  5:18 “… give thanks in all circumstances, for this is God’s will for you in  Christ Jesus.”

When no one seems to understand, or even to care: 
Psalm 55:22 “Cast your cares on the LORD and he will sustain you; he will never let the  righteous fall.”
Isaiah  40:11 “He tends his flock like a shepherd: He gathers the lambs in his arms  and carries them close to his heart; he gently leads those that have young.”

When you are being persecuted for your faith:
2 Peter 2:9 “the Lord knows  how to rescue godly men from trials and to hold the unrighteous for the day of  judgment.”
John 15:18 “If the world hates you, keep in mind that it hated me first.”

When  the nation, the world, and even the family and the church, seem to be  disintegrating:
Isaiah  14:24: “The LORD of hosts has sworn, saying, ‘Surely, as I have thought, so  it shall come to pass, And as I have purposed, so it shall stand.’”
Jeremiah 29:11 “For I  know the plans I have for you,” declares the LORD, “plans to prosper you and not  to harm you, plans to give you hope and a future.”

When life’s fears  and insecurities gang up on you:
Psalm 27:1 “The Lord is my light and my salvation—whom shall I fear? The Lord is the  stronghold of my life—of whom shall I be afraid?”
Luke 12:7 “Indeed, the very hairs of your head are all  numbered. Don’t be afraid; you are worth more than many sparrows.”
Romans 8:1 “There is, therefore, no condemnation to those  who are in Christ Jesus.”

When your mood is dark:
Psalm 118:24 “This is the  day the Lord has made. Let us rejoice, and be glad in it.”
Romans 8:29-30 “For those  whom God foreknew he also predestined to be conformed to the likeness of his  Son, that he might be the firstborn among many brothers. And those he called, he  also justified; those he justified, he also glorified.”

When worn out  and worn down to the point of giving up:
Hebrews  12:2-3 “Let us fix our eyes on Jesus, the author and completer of our faith,  who, for the joy set before Him endured the cross, despising its shame, and sat  down at the right hand of the throne of God. Consider him who endured such  opposition from sinful men, so that you will not grow weary and lose heart.”

When abandoned by everyone meaningful:
Deuteronomy 31:6 “Be  strong and courageous. Do not be afraid or terrified because of them, for the  LORD your God goes with you; he will never leave you nor forsake you.”
Hebrews 13:5-6 “… God has  said, ‘Never will I leave you, never will I forsake you.’ So we say with  confidence, ‘The Lord is my helper; I will not be afraid. What can man do to  me?’”

When friends and even family seem to be abandoning God: 
Psalm 100:5 “God’s faithfulness endures through all generations.”
2 Timothy 3:1-4 “But  mark this: There will be terrible times in the last days. People will be lovers  of themselves, lovers of money, boastful, proud, abusive, disobedient to their  parents, ungrateful, unholy, without love, unforgiving, slanderous, without  self-control, brutal, not lovers of the good, treacherous, rash, conceited,  lovers of pleasure rather than lovers of God”

When under powerful  temptation:
1  Corinthians 10:13 “No temptation has seized you except what is common to  man. And God is faithful; He will not let you be tempted beyond what you can  bear. But when you are tempted, he will also provide a way out so that you can  stand up under it.”
James 4:7-8 “Submit yourselves, then, to God. Resist the devil, and he will flee from you.  Come near to God and He will near to you.”
2 Timothy  1:12 “He is able to keep what I committed to Him against that day.”
Hebrews 2:18 “Because He  Himself suffered when He was tempted, He is able to help those who are being  tempted.”

When stung by your enemy’s false accusation:
1 Peter 3:14, 16 “But even if you should  suffer for what is right, you are blessed. … keeping a clear conscience, so that  those who speak maliciously against your good behavior in Christ may be ashamed  of their slander.”
Matthew  5:10 “Blessed are those who are persecuted because of righteousness, for  theirs in the kingdom of heaven. Blessed are you when people insult you,  persecute you, and falsely say all kinds of evil against you because of me.  Rejoice, and be exceeding glad, because great is your reward in heaven”
Romans 8:31-34 “What,  then, shall we say in response to this? If God is for us, who can be against us?  He who did not spare his own Son, but gave him up for us all—how will he not  also, along with him, graciously give us all things? Who will bring any charge  against those whom God has chosen? It is God who justifies. Who is he that  condemns? Christ Jesus, who died—more than that, who was raised to life—is at  the right hand of God and is also interceding for us.”

When  circumstances lead you to doubt God:
Psalm 42:5 “O  my soul, why are you downcast? Put your hope in God: for I will yet praise Him,  my Savior and my God.”
Mark 9:24 “I  do believe; help me overcome my unbelief!”

When gripped by  unrelenting anger and even hatred:
Ephesians  4:31 “Get rid of all bitterness, rage and anger, brawling and slander, along  with every form of malice. Be kind and compassionate to one another, forgiving  each other, just as in Christ God forgave you.”
James 1:19 “My dear brothers, take note of this: Everyone should be quick to listen, slow  to speak and slow to become angry, for man’s anger does not bring about the  righteous life that God desires.”
1 John 4:20 “If anyone says, ‘I love God,’ yet hates his brother, he is a liar. For anyone  who does not love his brother, whom he has seen, cannot love God, whom he has  not seen.”

When defeated with guilt, shame, and remorse:
1 John 1:9 “If we confess our  sins, He is faithful and just to forgive us our sins, and to cleanse us from all  unrighteousness.”
Romans  8:1-2 “Therefore, there is now no condemnation for those who are in Christ  Jesus, because through Christ Jesus the law of the Spirit of life set me free  from the law of sin and death.”

When about to go over the edge with  overwhelming demands, pressures, and expectations:
Matthew 11:28 “Come unto  me, all you that labor and are heavy laden, and I will give you rest.”
John 15:5 [Jesus said] “I am  the vine; you are the branches. If a man remains in me and I in him, he will  bear much fruit; apart from me you can do nothing.”
Philippians 4:13 “I can  do all things through Christ who strengthens me.”

When the road forks  unexpectedly, or when the multiplied factors of a crucial decision bring  darkening confusion:
James 1:5 “If  any of you lacks wisdom, he should ask God, who gives generously to all without  finding fault, and it will be given to him.”
1  Corinthians 14:33 “God is not the author of confusion.”
Proverbs 3:5-6 “Trust in  the Lord with all your heart. Lean not on your own understanding. In all your  ways acknowledge Him, and He shall direct your path.”

When you are  famished of soul, longing for purity and righteousness:
Matthew 5:6 “Blessed are those who hunger and thirst for  righteousness, for they will be filled.”
Psalm 23:3 “He leads me in paths of righteousness, for His name’s sake.”

When  all roads have been cut off so that only despair seems left:
1 Corinthians 10:13 “No temptation has seized you except what is common to man. And God is faithful;  he will not let you be tempted beyond what you can bear. But when you are  tempted, he will also provide a way out so that you can stand up under it.”
2  Corinthians 4:8 “We are hard pressed on every side, but not crushed;  perplexed, but not in despair.”

When the grave opens before you: 
John 3:16 “For  God so loved the world that he gave his one and only Son, that whoever believes  in him shall not perish but have eternal life.”
John  11:25-26 “I am the resurrection and the life. He who believes in me will  live, even though he dies; and whoever lives and believes in me will never die.
Hebrews  2:14-15 “Since the children have flesh and blood, He too shared in their  humanity so that by His death He might destroy him who holds the power of  death—that is, the devil—and free those who all their lives were held in slavery  by their fear of death.”

A blessing for all circumstances:
Romans 15:13  “May the God  of hope fill you with all joy and peace as you trust in him, so that you may  overflow with hope by the power of the Holy Spirit.”